{"id":361,"date":"2024-01-11T09:00:31","date_gmt":"2024-01-11T09:00:31","guid":{"rendered":"https:\/\/test.micreos.com\/?p=361"},"modified":"2026-06-12T14:17:13","modified_gmt":"2026-06-12T14:17:13","slug":"new-data-published-in-blood-supports-the-potential-of-engineered-endolysins-in-ctcl","status":"publish","type":"post","link":"https:\/\/micreos.com\/?p=361","title":{"rendered":"New Data Published in Blood Supports the Potential of Engineered Endolysins in CTCL"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">A study from the University of Copenhagen, published in <em>Blood<\/em>, provides new evidence that <em>Staphylococcus aureus<\/em> and its toxins can induce drug resistance in malignant T cells against therapies commonly used in cutaneous T-cell lymphoma (CTCL), including HDAC inhibitors and chemotherapies.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Importantly, the study showed that selective bacterial killing using a MICREOS engineered, <em>S. aureus<\/em>-targeting endolysin countered this drug-resistance effect.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">These findings further support the potential of engineered endolysins as a novel therapeutic modality in CTCL and highlight the opportunity for precision biologics to address pathogen-driven mechanisms of disease progression and treatment resistance.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/isim.ku.dk\/news-from-isim\/2024\/germs-can-offset-the-effect-of-cancer-therapy\">https:\/\/isim.ku.dk\/news-from-isim\/2024\/germs-can-offset-the-effect-of-cancer-therapy<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/doi.org\/10.1182\/blood.2023021671\">https:\/\/doi.org\/10.1182\/blood.2023021671<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n","protected":false},"excerpt":{"rendered":"<p>A study from the University of Copenhagen, published in Blood, provides new evidence that Staphylococcus aureus and its toxins can induce drug resistance in malignant T cells against therapies commonly used in cutaneous T-cell lymphoma (CTCL), including HDAC inhibitors and chemotherapies. Importantly, the study showed that selective bacterial killing using a MICREOS engineered, S. aureus-targeting [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":369,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"saved_in_kubio":true,"footnotes":""},"categories":[9,7],"tags":[],"class_list":["post-361","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-publication","category-upate"],"_links":{"self":[{"href":"https:\/\/micreos.com\/index.php?rest_route=\/wp\/v2\/posts\/361","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/micreos.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/micreos.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/micreos.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/micreos.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=361"}],"version-history":[{"count":2,"href":"https:\/\/micreos.com\/index.php?rest_route=\/wp\/v2\/posts\/361\/revisions"}],"predecessor-version":[{"id":365,"href":"https:\/\/micreos.com\/index.php?rest_route=\/wp\/v2\/posts\/361\/revisions\/365"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/micreos.com\/index.php?rest_route=\/wp\/v2\/media\/369"}],"wp:attachment":[{"href":"https:\/\/micreos.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=361"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/micreos.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=361"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/micreos.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=361"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}